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- accession：NM_153701
- 基因别名：IL12RB1
- 基因描述：Homo sapiens interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1146
- 翻译后氨基酸长度：381
- TranscriptVariant：This variant (2) differs in the 3' coding segment and 3' UTR compared to variant 1, resulting in a isoform (2) that contains a distinct and shorter C-terminus, as compared to isoform 1.
- 基因简介：The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
