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人TGIF1(NM_001278684)ORF克隆
人TGIF1(NM_001278684)ORF克隆
  • 商品货号:FO108521
  • ¥1100元
    已售 8 件 | 评价 0 人次 | 关注度 342
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    • accession:NM_001278684
    • 基因别名:TGIF1
    • 基因描述:Homo sapiens TGFB-induced factor homeobox 1 (TGIF1), transcript variant 10, mRNA.
    • 载体: 现货载体
    • CDS区长度:819
    • 翻译后氨基酸长度:272
    • TranscriptVariant:This variant (10) includes two alternate 5' exons, which result in a different 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    • 基因简介:The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
    • 载体信息:自有图片地址
    • 规格:10ul 质粒
    CDS区参考序列: 点击查看序列
    翻译后氨基酸参数序列: 点击查看序列