• accession：NM_174916
• 基因别名：UBR1
• 基因描述：Homo sapiens ubiquitin protein ligase E3 component n-recognin 1 (UBR1), mRNA.
• 载体：现货载体
• CDS区长度：5250
• 翻译后氨基酸长度：1749
• 基因简介：The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGCGGACGAGGAGGCTGGAGGTACTGAGAGGATGGAAATCAGCGCGGAGTTACCCCAGACCCCTCAGC
GTCTGGCATCTTGGTGGGATCAGCAAGTTGATTTTTATACTGCTTTCTTGCATCATTTGGCACAATTGGT
GCCAGAAATTTACTTTGCTGAAATGGACCCAGACTTGGAAAAGCAGGAGGAAAGTGTACAAATGTCAATA
TTCACTCCACTGGAATGGTACTTATTTGGAGAAGATCCAGATATTTGCTTAGAGAAATTGAAGCACAGTG
GAGCATTTCAGCTTTGTGGGAGGGTTTTCAAAAGTGGAGAGACAACCTATTCTTGCAGGGATTGTGCAAT
TGATCCAACATGTGTACTCTGTATGGACTGCTTCCAGGACAGTGTTCATAAAAATCATCGTTACAAGATG
CATACTTCTACTGGAGGAGGGTTCTGTGACTGTGGAGACACAGAGGCATGGAAAACTGGCCCTTTTTGTG
TAAATCATGAACCTGGAAGAGCAGGTACTATAAAAGAGAATTCACGCTGTCCGTTGAATGAAGAGGTAAT
TGTCCAAGCCAGGAAAATATTTCCTTCAGTGATAAAATATGTCGTAGAAATGACTATATGGGAAGAGGAA
AAAGAACTGCCTCCTGAACTCCAGATAAGGGAGAAAAATGAAAGATACTATTGTGTCCTTTTCAATGATG
AACACCATTCATATGACCACGTCATATACAGCCTACAAAGAGCTCTTGACTGTGAGCTCGCAGAGGCCCA
GTTGCATACCACTGCCATTGACAAAGAGGGTCGTCGGGCTGTTAAAGCGGGAGCTTATGCTGCTTGCCAG
GAAGCAAAGGAAGATATAAAGAGTCATTCAGAAAATGTCTCTCAACATCCACTTCATGTAGAAGTATTAC
ACTCAGAGATTATGGCTCATCAGAAATTTGCTTTGCGTCTTGGTTCCTGGATGAACAAAATTATGAGCTA
TTCAAGTGACTTTAGGCAGATCTTTTGCCAAGCATGCCTTAGAGAAGAACCTGACTCGGAGAATCCCTGT
CTCATAAGCAGGTTAATGCTTTGGGATGCAAAGCTTTATAAAGGTGCCCGTAAGATCCTTCATGAATTGA
TCTTCAGCAGTTTTTTTATGGAGATGGAATACAAAAAACTCTTTGCTATGGAATTTGTGAAGTATTATAA
ACAACTGCAGAAAGAATATATCAGTGATGATCATGACAGAAGTATCTCTATAACTGCACTTTCAGTTCAG
ATGTTTACTGTTCCTACTCTGGCTCGACATCTTATTGAAGAGCAGAATGTTATCTCTGTCATTACTGAAA
CTCTGCTAGAAGTTTTACCTGAGTACTTGGACAGGAACAATAAATTCAACTTCCAGGGTTATAGCCAGGA
CAAATTGGGAAGAGTATATGCAGTAATATGTGACCTAAAGTATATCCTGATCAGCAAACCCACAATATGG
ACAGAAAGATTAAGAATGCAGTTCCTTGAAGGTTTTCGATCTTTTTTGAAGATTCTTACCTGTATGCAGG
GAATGGAAGAAATCCGAAGACAGGTTGGGCAACACATTGAAGTGGATCCTGATTGGGAGGCTGCCATTGC
TATACAGATGCAATTGAAGAATATTTTACTCATGTTCCAAGAGTGGTGTGCTTGTGATGAAGAACTCTTA
CTTGTGGCTTATAAAGAATGTCACAAAGCTGTGATGAGGTGCAGTACCAGTTTCATATCTAGTAGCAAGA
CAGTAGTACAATCGTGTGGACATAGTTTGGAAACAAAGTCCTACAGAGTATCTGAGGATCTTGTAAGCAT
ACATCTGCCACTCTCTAGGACCCTTGCTGGTCTTCATGTACGTTTAAGCAGGCTGGGTGCTGTTTCAAGA
CTGCATGAATTTGTGTCTTTTGAGGACTTTCAAGTAGAGGTACTAGTGGAATATCCTTTACGTTGTCTGG
TGTTGGTTGCCCAGGTTGTTGCTGAGATGTGGCGAAGAAATGGACTGTCTCTTATTAGCCAGGTGTTTTA
TTACCAAGATGTTAAGTGCAGAGAAGAAATGTATGATAAAGATATCATCATGCTTCAGATTGGTGCATCT
TTAATGGATCCCAATAAGTTCTTGTTACTGGTACTTCAGAGGTATGAACTTGCCGAGGCTTTTAACAAGA
CCATATCTACAAAAGACCAGGATTTGATTAAACAATATAATACACTAATAGAAGAAATGCTTCAGGTCCT
CATCTATATTGTGGGTGAGCGTTATGTACCTGGAGTGGGAAATGTGACCAAAGAAGAGGTCACAATGAGA
GAAATCATTCACTTGCTTTGCATTGAACCCATGCCACACAGTGCCATTGCCAAAAATTTACCTGAGAATG
AAAATAATGAAACTGGCTTAGAGAATGTCATAAACAAAGTGGCCACATTTAAGAAACCAGGTGTATCAGG
CCATGGAGTTTATGAACTAAAAGATGAATCACTGAAAGACTTCAATATGTACTTTTATCATTACTCCAAA
ACCCAGCATAGCAAGGCTGAACATATGCAGAAGAAAAGGAGAAAACAAGAAAACAAAGATGAAGCATTGC
CGCCACCACCACCTCCTGAATTCTGCCCTGCTTTCAGCAAAGTGATTAACCTTCTCAACTGTGATATCAT
GATGTACATTCTCAGGACCGTATTTGAGCGGGCAATAGACACAGATTCTAACTTGTGGACCGAAGGGATG
CTCCAAATGGCTTTTCATATTCTGGCATTGGGTTTACTAGAAGAGAAGCAACAGCTTCAAAAAGCTCCTG
AAGAAGAAGTAACATTTGACTTTTATCATAAGGCTTCAAGATTGGGAAGTTCAGCCATGAATATACAAAT
GCTTTTGGAAAAACTCAAAGGAATTCCCCAGTTAGAAGGCCAGAAGGACATGATAACGTGGATACTTCAG
ATGTTTGACACAGTGAAGCGATTAAGAGAAAAATCTTGTTTAATTGTAGCAACCACATCAGGATCGGAAT
CTATTAAGAATGATGAGATTACTCATGATAAAGAAAAAGCAGAACGAAAAAGAAAAGCTGAAGCTGCTAG
GCTACATCGCCAGAAGATCATGGCTCAGATGTCTGCCTTACAGAAAAACTTCATTGAAACTCATAAACTC
ATGTATGACAATACATCAGAAATGCCTGGGAAAGAAGATTCCATTATGGAGGAAGAGAGCACCCCAGCAG
TCAGTGACTACTCTAGAATTGCTTTGGGTCCTAAACGGGGTCCATCTGTTACTGAAAAGGAGGTGCTGAC
GTGCATCCTTTGCCAAGAAGAACAGGAGGTGAAAATAGAAAATAATGCCATGGTATTATCGGCCTGTGTC
CAGAAATCTACTGCCTTAACCCAGCACAGGGGAAAACCCATAGAACTCTCAGGAGAAGCCCTAGACCCAC
TTTTCATGGATCCAGACTTGGCATATGGAACTTATACAGGAAGCTGTGGTCATGTAATGCACGCAGTGTG
CTGGCAGAAGTATTTTGAAGCTGTACAGCTGAGCTCTCAGCAGCGCATTCATGTTGACCTTTTTGACTTG
GAAAGTGGAGAATATCTTTGCCCTCTTTGCAAATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGC
AACCTCAAAAGATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACA
GACTGTTCTGGCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTC
TTTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTTGAGTCTTCGA
TTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTGCCACAACAATTTATAGAATTGGATTGAA
AGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGACCTGGAGCACCTGCGCTTTCACTATCCAG
GCAATTGAAAATCTATTGGGAGATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATG
GTCTGAAAGCATTAATGCAGTTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACA
TCTGGTTCGTCTTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTTCTGTCTATA
GATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATTGGGATGACCCTGTTGATC
TGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATTTGATCACCATGGCACACAT
GCTTCAGATACTACTTACAGTAGACACAGGCCTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCT
CATTCCGCATCTTCTTTCTTTGCAGAAATTTCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTG
GCTGGTATTTGTGGGTCTCACTGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCA
CTATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACAGTGCACTC
TGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTGTAAGGCCCT
TGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAAAAAAACACCGTGGTCAGGTA
CCCTAGAAAAAGAAATAGTTTGATAGAGCTTCCTGATGACTATAGCTGCCTCCTGAATCAAGCTTCTCAT
TTCAGGTGCCCACGGTCTGCAGATGATGAGCGAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATAC
TATGTTCTCAGAACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGC
ACTTCACTGTGGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGT
AAAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCTGGCCTGAAGA
GGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGCTCCATTTGGTCTGGCAACAACACTGCAT
TATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGTTATTTGGATTCAACTGGCAGTTACTGTGA

翻译后氨基酸参数序列： 点击查看序列

ATGGCGGACGAGGAGGCTGGAGGTACTGAGAGGATGGAAATCAGCGCGGAGTTACCCCAGACCCCTCAGC
GTCTGGCATCTTGGTGGGATCAGCAAGTTGATTTTTATACTGCTTTCTTGCATCATTTGGCACAATTGGT
GCCAGAAATTTACTTTGCTGAAATGGACCCAGACTTGGAAAAGCAGGAGGAAAGTGTACAAATGTCAATA
TTCACTCCACTGGAATGGTACTTATTTGGAGAAGATCCAGATATTTGCTTAGAGAAATTGAAGCACAGTG
GAGCATTTCAGCTTTGTGGGAGGGTTTTCAAAAGTGGAGAGACAACCTATTCTTGCAGGGATTGTGCAAT
TGATCCAACATGTGTACTCTGTATGGACTGCTTCCAGGACAGTGTTCATAAAAATCATCGTTACAAGATG
CATACTTCTACTGGAGGAGGGTTCTGTGACTGTGGAGACACAGAGGCATGGAAAACTGGCCCTTTTTGTG
TAAATCATGAACCTGGAAGAGCAGGTACTATAAAAGAGAATTCACGCTGTCCGTTGAATGAAGAGGTAAT
TGTCCAAGCCAGGAAAATATTTCCTTCAGTGATAAAATATGTCGTAGAAATGACTATATGGGAAGAGGAA
AAAGAACTGCCTCCTGAACTCCAGATAAGGGAGAAAAATGAAAGATACTATTGTGTCCTTTTCAATGATG
AACACCATTCATATGACCACGTCATATACAGCCTACAAAGAGCTCTTGACTGTGAGCTCGCAGAGGCCCA
GTTGCATACCACTGCCATTGACAAAGAGGGTCGTCGGGCTGTTAAAGCGGGAGCTTATGCTGCTTGCCAG
GAAGCAAAGGAAGATATAAAGAGTCATTCAGAAAATGTCTCTCAACATCCACTTCATGTAGAAGTATTAC
ACTCAGAGATTATGGCTCATCAGAAATTTGCTTTGCGTCTTGGTTCCTGGATGAACAAAATTATGAGCTA
TTCAAGTGACTTTAGGCAGATCTTTTGCCAAGCATGCCTTAGAGAAGAACCTGACTCGGAGAATCCCTGT
CTCATAAGCAGGTTAATGCTTTGGGATGCAAAGCTTTATAAAGGTGCCCGTAAGATCCTTCATGAATTGA
TCTTCAGCAGTTTTTTTATGGAGATGGAATACAAAAAACTCTTTGCTATGGAATTTGTGAAGTATTATAA
ACAACTGCAGAAAGAATATATCAGTGATGATCATGACAGAAGTATCTCTATAACTGCACTTTCAGTTCAG
ATGTTTACTGTTCCTACTCTGGCTCGACATCTTATTGAAGAGCAGAATGTTATCTCTGTCATTACTGAAA
CTCTGCTAGAAGTTTTACCTGAGTACTTGGACAGGAACAATAAATTCAACTTCCAGGGTTATAGCCAGGA
CAAATTGGGAAGAGTATATGCAGTAATATGTGACCTAAAGTATATCCTGATCAGCAAACCCACAATATGG
ACAGAAAGATTAAGAATGCAGTTCCTTGAAGGTTTTCGATCTTTTTTGAAGATTCTTACCTGTATGCAGG
GAATGGAAGAAATCCGAAGACAGGTTGGGCAACACATTGAAGTGGATCCTGATTGGGAGGCTGCCATTGC
TATACAGATGCAATTGAAGAATATTTTACTCATGTTCCAAGAGTGGTGTGCTTGTGATGAAGAACTCTTA
CTTGTGGCTTATAAAGAATGTCACAAAGCTGTGATGAGGTGCAGTACCAGTTTCATATCTAGTAGCAAGA
CAGTAGTACAATCGTGTGGACATAGTTTGGAAACAAAGTCCTACAGAGTATCTGAGGATCTTGTAAGCAT
ACATCTGCCACTCTCTAGGACCCTTGCTGGTCTTCATGTACGTTTAAGCAGGCTGGGTGCTGTTTCAAGA
CTGCATGAATTTGTGTCTTTTGAGGACTTTCAAGTAGAGGTACTAGTGGAATATCCTTTACGTTGTCTGG
TGTTGGTTGCCCAGGTTGTTGCTGAGATGTGGCGAAGAAATGGACTGTCTCTTATTAGCCAGGTGTTTTA
TTACCAAGATGTTAAGTGCAGAGAAGAAATGTATGATAAAGATATCATCATGCTTCAGATTGGTGCATCT
TTAATGGATCCCAATAAGTTCTTGTTACTGGTACTTCAGAGGTATGAACTTGCCGAGGCTTTTAACAAGA
CCATATCTACAAAAGACCAGGATTTGATTAAACAATATAATACACTAATAGAAGAAATGCTTCAGGTCCT
CATCTATATTGTGGGTGAGCGTTATGTACCTGGAGTGGGAAATGTGACCAAAGAAGAGGTCACAATGAGA
GAAATCATTCACTTGCTTTGCATTGAACCCATGCCACACAGTGCCATTGCCAAAAATTTACCTGAGAATG
AAAATAATGAAACTGGCTTAGAGAATGTCATAAACAAAGTGGCCACATTTAAGAAACCAGGTGTATCAGG
CCATGGAGTTTATGAACTAAAAGATGAATCACTGAAAGACTTCAATATGTACTTTTATCATTACTCCAAA
ACCCAGCATAGCAAGGCTGAACATATGCAGAAGAAAAGGAGAAAACAAGAAAACAAAGATGAAGCATTGC
CGCCACCACCACCTCCTGAATTCTGCCCTGCTTTCAGCAAAGTGATTAACCTTCTCAACTGTGATATCAT
GATGTACATTCTCAGGACCGTATTTGAGCGGGCAATAGACACAGATTCTAACTTGTGGACCGAAGGGATG
CTCCAAATGGCTTTTCATATTCTGGCATTGGGTTTACTAGAAGAGAAGCAACAGCTTCAAAAAGCTCCTG
AAGAAGAAGTAACATTTGACTTTTATCATAAGGCTTCAAGATTGGGAAGTTCAGCCATGAATATACAAAT
GCTTTTGGAAAAACTCAAAGGAATTCCCCAGTTAGAAGGCCAGAAGGACATGATAACGTGGATACTTCAG
ATGTTTGACACAGTGAAGCGATTAAGAGAAAAATCTTGTTTAATTGTAGCAACCACATCAGGATCGGAAT
CTATTAAGAATGATGAGATTACTCATGATAAAGAAAAAGCAGAACGAAAAAGAAAAGCTGAAGCTGCTAG
GCTACATCGCCAGAAGATCATGGCTCAGATGTCTGCCTTACAGAAAAACTTCATTGAAACTCATAAACTC
ATGTATGACAATACATCAGAAATGCCTGGGAAAGAAGATTCCATTATGGAGGAAGAGAGCACCCCAGCAG
TCAGTGACTACTCTAGAATTGCTTTGGGTCCTAAACGGGGTCCATCTGTTACTGAAAAGGAGGTGCTGAC
GTGCATCCTTTGCCAAGAAGAACAGGAGGTGAAAATAGAAAATAATGCCATGGTATTATCGGCCTGTGTC
CAGAAATCTACTGCCTTAACCCAGCACAGGGGAAAACCCATAGAACTCTCAGGAGAAGCCCTAGACCCAC
TTTTCATGGATCCAGACTTGGCATATGGAACTTATACAGGAAGCTGTGGTCATGTAATGCACGCAGTGTG
CTGGCAGAAGTATTTTGAAGCTGTACAGCTGAGCTCTCAGCAGCGCATTCATGTTGACCTTTTTGACTTG
GAAAGTGGAGAATATCTTTGCCCTCTTTGCAAATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGC
AACCTCAAAAGATAAACAGTGAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACA
GACTGTTCTGGCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTC
TTTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTTGAGTCTTCGA
TTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTGCCACAACAATTTATAGAATTGGATTGAA
AGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTGACCTGGAGCACCTGCGCTTTCACTATCCAG
GCAATTGAAAATCTATTGGGAGATGAAGGAAAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATG
GTCTGAAAGCATTAATGCAGTTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACA
TCTGGTTCGTCTTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTTCTGTCTATA
GATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATTGGGATGACCCTGTTGATC
TGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCATTTGATCACCATGGCACACAT
GCTTCAGATACTACTTACAGTAGACACAGGCCTACCCCTTGCTCAGGTTCAAGAAGACAGTGAAGAGGCT
CATTCCGCATCTTCTTTCTTTGCAGAAATTTCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTG
GCTGGTATTTGTGGGTCTCACTGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCA
CTATTTACTTGGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACAGTGCACTC
TGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACTGTAAGGCCCT
TGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAAAAAAACACCGTGGTCAGGTA
CCCTAGAAAAAGAAATAGTTTGATAGAGCTTCCTGATGACTATAGCTGCCTCCTGAATCAAGCTTCTCAT
TTCAGGTGCCCACGGTCTGCAGATGATGAGCGAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATAC
TATGTTCTCAGAACATTTGCTGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGC
ACTTCACTGTGGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGT
AAAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCTGGCCTGAAGA
GGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGCTCCATTTGGTCTGGCAACAACACTGCAT
TATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATGTTATTTGGATTCAACTGGCAGTTACTGTGA