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- accession：NM_000842
- 基因别名：GRM5
- 基因描述：Homo sapiens glutamate receptor, metabotropic 5 (GRM5), transcript variant b, mRNA.
- 载体：现货载体
- CDS区长度：3543
- 翻译后氨基酸长度：1180
- TranscriptVariant：This variant (b) lacks a coding exon, as compared to variant a. The resulting isoform (b) lacks an internal segment in the C-terminal region, as compared to isoform a.
- 基因简介：L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
