• 商品货号：A16826

• 名称：Avitinib (AC0010)
• 简介：Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
• CASNO：1557267-42-1
• 分子式：C26H26FN7O2
• 分子量：487.53
• SMILES：C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O
• 保持条件：at -20°C 3 years Powder
• 同名：AC-0010, AC 0010, Abivertinib
• 纯度：>98%
• 应用：irreversible EGFR inhibitor
• 作用机制：Inhibitor