- 商品货号:F139851
- accession:NM_012308
- 基因别名:KDM2A
- 基因描述:Homo sapiens lysine (K)-specific demethylase 2A (KDM2A), transcript variant 1, mRNA.
- 载体:现货载体
- CDS区长度:3489
- 翻译后氨基酸长度:1162
- TranscriptVariant:This variant (1) represents the longest transcript and encodes the longer isoform (a).
- 基因简介:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
- 载体信息:自有图片地址
- 规格:10ul 质粒
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