- 商品货号:F142843
- accession:NM_021903
- 基因别名:GABBR1
- 基因描述:Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 2, mRNA.
- 载体:现货载体
- CDS区长度:2535
- 翻译后氨基酸长度:844
- TranscriptVariant:This variant (2) lacks four 5' exons and uses an alternative 5' exon, as compared to variant 1. It encodes isoform b which has a distinct N-terminus compared to isoform a.
- 基因简介:Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]
- 载体信息:自有图片地址
- 规格:10ul 质粒
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