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- accession：NM_001142397
- 基因别名：Gm672; KIAA0427
- 基因描述：Homo sapiens CBP80/20-dependent translation initiation factor (CTIF), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1803
- 翻译后氨基酸长度：600
- TranscriptVariant：This variant (2) contains an additional 5' non-coding exon, and uses an alternate donor splice site at one of the internal coding exons compared to transcript variant 1. This results in an isoform (2) with two additional amino acids compared to isoform 1.
- 基因简介：CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
