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- accession：NM_001282382
- 基因别名：EAP1; PTTG; HPTTG; TUTR1
- 基因描述：Homo sapiens pituitary tumor-transforming 1 (PTTG1), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：609
- 翻译后氨基酸长度：202
- TranscriptVariant：This variant (1) represents the longest transcript. All three variants encode the same protein.
- 基因简介：The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
