• 靶点-Target： Bcl-6
• MW(Observed)： 80kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Acetyl
• 推荐稀释比： WB 1:1000-2000;ELISA 1:5000-20000
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)
• 特异性： This antibody detects endogenous levels of Human，Mouse，Rat Bcl-6 (Acetyl Lys379)
• 基因名称： BCL6 BCL5 LAZ3 ZBTB27 ZNF51
• 蛋白名称： Bcl-6 (Acetyl Lys379)
• Organism-1： Human
• 基因ID-1： 604
• SwissProt-1： P41182
• Organism-2： Mouse
• 基因ID-2： 12053
• SwissProt-2： P41183
• 背景： disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.，disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.，disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.，function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.，induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS， CD40L and zymosan.，PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.，similarity:Contains 1 BTB (POZ) domain.，similarity:Contains 6 C2H2-type zinc fingers.，subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.，tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.，
• 细胞定位： Nucleus .

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