• 靶点-Target： JNK1
• MW(Observed)： 46，54kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000;ICC 1:100;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human JNK1 protein fragments expressed in E.coli.
• 特异性： This antibody detects endogenous levels of JNK1 and does not cross-react with related proteins.
• 基因名称： mapk8
• Organism-1： Human
• 基因ID-1： 5599
• SwissProt-1： P45983
• Organism-2： Mouse
• SwissProt-2： Q91Y86
• 背景： The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals， and are involved in a wide variety of cellular processes such as proliferation， differentiation， transcription regulation and development. This kinase is activated by various cell stimuli， and targets specific transcription factors， and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis， which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation， apoptosis and differentiation. Several alternatively spl
• 细胞定位： Cytoplasm . Nucleus . Cell junction， synapse . In the cortical neurons， predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .

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