• 靶点-Target： AQP4
• MW(Observed)： 48kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000;IF 1:100-200;IHC 1:50-300
• 组成： PBS， pH 7.4， containing 0.5%BSA， 0.02% sodium azide as Preservative and 50% Glycerol.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 克隆号： 4H1
• 免疫原： Synthetic Peptide of Aquaporin 4
• 特异性： The antibody detects endogenous Aquaporin 4 proteins.
• 基因名称： AQP4
• 蛋白名称： Aquaporin-4
• Organism-1： Human
• 基因ID-1： 361
• SwissProt-1： P55087
• Organism-2： Mouse
• 基因ID-2： 11829
• SwissProt-2： P55088
• Organism-3： Rat
• 基因ID-3： 25293
• SwissProt-3： P47863
• 背景： This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq， Dec 2015]，
• 细胞定位： Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endosome membrane . Cell membrane， sarcolemma ; Multi-pass membrane protein . Cell projection . Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. .

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