• 靶点-Target： FH
• MW(Observed)： 50kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:3000;IF 1:200;IHC 1:50-300
• 组成： PBS， pH 7.4， containing 0.5%BSA， 0.02% sodium azide as Preservative and 50% Glycerol.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 克隆号： 7F1
• 免疫原： Synthetic Peptide of FH
• 特异性： The antibody detects endogenous FH proteins.
• 基因名称： FH
• 蛋白名称： Fumarate hydratase， mitochondrial
• Organism-1： Human
• 基因ID-1： 2271
• SwissProt-1： P07954
• Organism-2： Mouse
• 基因ID-2： 14194
• SwissProt-2： P97807
• Organism-3： Rat
• SwissProt-3： P14408
• 背景： The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle， or Krebs cycle， and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form， differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion， where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq， Jul 2008]，
• 细胞定位： [Isoform Mitochondrial]: Mitochondrion .; [Isoform Cytoplasmic]: Cytoplasm， cytosol . Nucleus . Chromosome . Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. .

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