• 靶点-Target： DHI2
• MW(Observed)： 44kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:500-2000;ELISA 1:5000-20000
• 组成： PBS， 50% glycerol， 0.05% Proclin 300， 0.05%BSA
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： Synthesized peptide derived from part region of human protein
• 特异性： DHI2 Polyclonal Antibody detects endogenous levels of protein.
• 基因名称： HSD11B2 HSD11K
• 蛋白名称： Corticosteroid 11-beta-dehydrogenase isozyme 2 (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (11-beta-hydroxysteroid dehydrogenase type II) (-HSD11 type II) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (11-beta-HSD)
• Organism-1： Human
• 基因ID-1： 3291
• SwissProt-1： P80365
• Organism-2： Mouse
• SwissProt-2： P51661
• Organism-3： Rat
• SwissProt-3： P50233
• 背景： hydroxysteroid 11-beta dehydrogenase 2(HSD11B2) Homo sapiens There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase， a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme， encoded by this gene， has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney， the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone， thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor， such as the placenta and testis， it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol， particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mine
• 细胞定位： Microsome . Endoplasmic reticulum .

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