• 靶点-Target： SH-PTP1
• MW(Observed)： 67kD
• 宿主物种-Host Species： Rabbit
• 同种型-Isotype： IgG
• 修饰-Modification： Phospho
• 推荐稀释比： WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 浓度： 1 mg/ml
• 克隆性： Polyclonal
• 免疫原： The antiserum was produced against synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr536. AA range:502-551
• 特异性： Phospho-SH-PTP1 (Y536) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y536.
• 基因名称： PTPN6
• 蛋白名称： Tyrosine-protein phosphatase non-receptor type 6
• Organism-1： Human
• 基因ID-1： 5777
• SwissProt-1： P29350
• Organism-2： Mouse
• 基因ID-2： 15170
• SwissProt-2： P29351
• Organism-3： Rat
• 基因ID-3： 116689
• SwissProt-3： P81718
• 背景： The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth， differentiation， mitotic cycle， and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains， which act as protein phospho-tyrosine binding domains， and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells， and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with， and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene， which encode distinct isoforms， have been reported. [provided by RefSeq， Jul
• 细胞定位： Cytoplasm. Nucleus. In neurons， translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .

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