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- accession：NM_001128171
- 基因别名：EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik
- 基因描述：Mus musculus cylindromatosis (turban tumor syndrome) (Cyld), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：2859
- 翻译后氨基酸长度：952
- TranscriptVariant：This variant (4) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode isoform b.
- 基因简介：This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
