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- accession：NM_001195498
- 基因别名：CL2; CLICK2; Dcamkl2; AU044875; Click-II; 6330415M09Rik
- 基因描述：Mus musculus doublecortin-like kinase 2 (Dclk2), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：2148
- 翻译后氨基酸长度：715
- TranscriptVariant：This variant (4) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264), and represents the longest transcript. It has an additional 3 nts at an alternate splice site and an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (4) has an extra aa in the middle region and has a shorter and different C-terminus, as compared to isoform 1.
- 基因简介：This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
