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- accession：NM_027013
- 基因别名：Scnm1-ps; 3110001I17Rik
- 基因描述：Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：561
- 翻译后氨基酸长度：186
- TranscriptVariant：This variant (1) represents the longer transcript and encodes the longer isoform (1). The C-terminus of this isoform is truncated compared to that of the same variant in mouse strains not derived from C57BL6. This truncated isoform is not able to counteract the deleterious effects of the Scn8amedJ mutation whereas the longer isoform found in non-C57BL6 strains can partially overcome these effects.
- 基因简介：Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
