• accession：NM_001271561
• 基因别名：PRNP
• 基因描述：Homo sapiens prion protein (PRNP), transcript variant 6, mRNA.
• 载体：现货载体
• CDS区长度：222
• 翻译后氨基酸长度：73
• TranscriptVariant：This variant (6) represents the longest transcript but encodes a shorter protein from an overlapping reading frame, compared to variant 1. Alternative prion protein (AltPrp) has no similarity to other isoforms encoded by this gene and localizes to the outer mitochondrial membrane.
• 基因简介：The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGAACACTGGGGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGC
GGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCC
ATGGTGGTGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAA
CAAGCCGAGTAA

翻译后氨基酸参数序列： 点击查看序列

ATGGAACACTGGGGGCAGCCGATACCCGGGGCAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGC
GGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCC
ATGGTGGTGGCTGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAA
CAAGCCGAGTAA