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- accession：NM_031968
- 基因别名：NARF
- 基因描述：Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1509
- 翻译后氨基酸长度：502
- TranscriptVariant：This variant (2) contains an additional in-frame coding exon created by exonization of Alu sequence, and elimination of a premature stop codon by RNA editing (PMID:17326827), compared to transcript variant 1. This results in an isoform (b) that contains a 46 aa protein segment that is missing from isoform a.
- 基因简介：Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
