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- accession：NM_001145031
- 基因别名：PLAU
- 基因描述：Homo sapiens plasminogen activator, urokinase (PLAU), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1245
- 翻译后氨基酸长度：414
- TranscriptVariant：This variant (2) is alternatively spliced at the 5' end compared to transcript variant 1, which can result in translation initiation from a downstream AUG (by leaky scanning) and a shorter isoform (2) with a distinct N-terminus compared to isoform 1. Isoform 2 retains the cleavage sites for generation of short chain A and chain B.
- 基因简介：This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
