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- accession：NM_001243126
- 基因别名：KLK7
- 基因描述：Homo sapiens kallikrein-related peptidase 7 (KLK7), transcript variant 4, mRNA.
- 载体：现货载体
- CDS区长度：741
- 翻译后氨基酸长度：246
- TranscriptVariant：This variant (4) uses an alternate upstream start codon, compared to variant 1, which is only present in the minor allele due to a single nucleotide polymorphism. The 5' CDS is in a different reading frame, but this variant lacks an exon in the coding region which results in a frameshift and in-frame 3' CDS, compared to variant 1. The encoded isoform (3) has a unique N-terminus and is shorter than isoform 1.
- 基因简介：This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
