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- accession：NM_001018020
- 基因别名：TPM1
- 基因描述：Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 7, mRNA.
- 载体：现货载体
- CDS区长度：855
- 翻译后氨基酸长度：284
- TranscriptVariant：This variant (7) contains alternate, in-frame exons in the coding region, compared to variant 1. It encodes isoform 7, which has distinct N- and C-termini, compared to isoform 1.
- 基因简介：This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
