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- accession：NM_001126118
- 基因别名：TP53
- 基因描述：Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA.
- 载体：现货载体
- CDS区长度：1065
- 翻译后氨基酸长度：354
- TranscriptVariant：This variant (8, also known as p53I2) differs in the 5' UTR, and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (g, also known as delta40p53alpha or deltaNp53) has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:21112961.
- 基因简介：This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
