- accession:NM_001278186
- 基因别名:HERC4
- 基因描述:Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4), transcript variant 4, mRNA.
- 载体:现货载体
- CDS区长度:2385
- 翻译后氨基酸长度:794
- TranscriptVariant:This variant (4) lacks two alternate exons compared to variant 1, and one causes a frameshift. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter and distinct N-terminus and lacking an alternate internal segment, compared to isoform 1.
- 基因简介:HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
- 规格:10ul 质粒
CDS区参考序列: 点击查看序列翻译后氨基酸参数序列: 点击查看序列