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- accession：NM_153335
- 基因别名：STRADA
- 基因描述：Homo sapiens STE20-related kinase adaptor alpha (STRADA), transcript variant 3, mRNA.
- 载体：现货载体
- CDS区长度：1047
- 翻译后氨基酸长度：348
- TranscriptVariant：This variant (3) uses an alternate splice site and lacks two alternate exons in the 5' coding region, and uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) lacks an internal segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 1.
- 基因简介：The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
