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- accession：NM_005699
- 基因别名：IL18BP
- 基因描述：Homo sapiens interleukin 18 binding protein (IL18BP), transcript variant C, mRNA.
- 载体：现货载体
- CDS区长度：600
- 翻译后氨基酸长度：199
- TranscriptVariant：This variant (C) is alternatively spliced in the 3' coding region compared to variant A. This results in a frame-shift, and a longer isoform (c, also known as IL-18BPc) with a distinct C-terminus compared to isoform a. This isoform retains the ability to bind IL-18 (PMID:10655506).
- 基因简介：The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
