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人 VEGFA (NM_001287044) cDNA克隆
人 VEGFA (NM_001287044) cDNA克隆
  • 商品货号:FC119035
  • 已售 5 件 | 评价 0 人次 | 关注度 251
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    • accession:NM_001287044
    • 基因别名:VEGFA
    • 基因描述:Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 10, mRNA.
    • 载体:现货载体
    • CDS区长度:492
    • 翻译后氨基酸长度:163
    • TranscriptVariant:This variant (10) has an alternate 5' exon, which results in translation initiation at a downstream AUG start codon, and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (s) has a shorter N-terminus and lacks an internal segment, compared to isoform a.
    • 基因简介:This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
    • 规格:10ul 质粒
    CDS区参考序列: 点击查看序列
    翻译后氨基酸参数序列: 点击查看序列