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人ACE2(NM_021804)ORF克隆 CALU-3细胞 vero E6非洲绿猴肾细胞
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人 AKAP13 (NM_007200) cDNA克隆
人 AKAP13 (NM_007200) cDNA克隆
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    • accession：NM_007200
    • 基因别名：AKAP13
    • 基因描述：Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 2, mRNA.
    • 载体：现货载体
    • CDS区长度：8442
    • 翻译后氨基酸长度：2813
    • TranscriptVariant：This variant (2) contains an internal alternate in-frame exon in the coding region, as compared to variant 1. Isoform 2 differs from isoform 1 in a small middle region.
    • 基因简介：The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
    • 规格：10ul 质粒
    CDS区参考序列： 点击查看序列
    翻译后氨基酸参数序列： 点击查看序列
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