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人 ATM (NM_000051) cDNA克隆
人 ATM (NM_000051) cDNA克隆
  • 商品货号:FC121950
  • 已售 6 件 | 评价 0 人次 | 关注度 413
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    • accession:NM_000051
    • 基因别名:ATM
    • 基因描述:Homo sapiens ataxia telangiectasia mutated (ATM), mRNA.
    • 载体:现货载体
    • CDS区长度:9171
    • 翻译后氨基酸长度:3056
    • 基因简介:The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
    • 规格:10ul 质粒
    CDS区参考序列: 点击查看序列
    翻译后氨基酸参数序列: 点击查看序列