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- accession：NM_001039715
- 基因别名：DIO1
- 基因描述：Homo sapiens deiodinase, iodothyronine, type I (DIO1), transcript variant 3, mRNA.
- 载体：现货载体
- CDS区长度：606
- 翻译后氨基酸长度：201
- TranscriptVariant：This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform c). Unlike isoform a, isoform c does not contain selenocysteine.
- 基因简介：The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
