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- accession：NM_001032409
- 基因别名：OAS1
- 基因描述：Homo sapiens 2'-5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 3, mRNA.
- 载体：现货载体
- CDS区长度：1245
- 翻译后氨基酸长度：414
- TranscriptVariant：This variant (3) uses an alternate, in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, also known as p48, which has a longer, distinct C-terminus, compared to isoform 1.
- 基因简介：This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
