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- accession：NM_001178121
- 基因别名：ABI1
- 基因描述：Homo sapiens abl-interactor 1 (ABI1), transcript variant 8, mRNA.
- 载体：现货载体
- CDS区长度：1341
- 翻译后氨基酸长度：446
- TranscriptVariant：This variant (8) lacks three alternate in-frame coding exons and uses a different splice site, compared to variant 1. The resulting protein (isoform h) has the same N- and C-termini but is shorter when it is compared to isoform a. This isoform has also been called the 'long' isoform.
- 基因简介：This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
