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- accession：NM_001146202
- 基因别名：RASGRP4
- 基因描述：Homo sapiens RAS guanyl releasing protein 4 (RASGRP4), transcript variant b, mRNA.
- 载体：现货载体
- CDS区长度：1980
- 翻译后氨基酸长度：659
- TranscriptVariant：This variant (b) uses an alternate in-frame splice junction compared to variant a. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
- 基因简介：The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
