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- accession：NM_001042726
- 基因别名：Pcdh8
- 基因描述：Mus musculus protocadherin 8 (Pcdh8), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：2922
- 翻译后氨基酸长度：973
- TranscriptVariant：This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a protein (isoform 2) with a shorter cytoplasmic domain, compared to isoform 1.
- 基因简介：This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
