×
![]()
- accession：NM_001128605
- 基因别名：Psen2
- 基因描述：Mus musculus presenilin 2 (Psen2), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：1347
- 翻译后氨基酸长度：448
- TranscriptVariant：This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
- 基因简介：This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
