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- accession：NM_146134
- 基因别名：Aph1a
- 基因描述：Mus musculus anterior pharynx defective 1a homolog (C. elegans) (Aph1a), transcript variant 2, mRNA.
- 载体：现货载体
- CDS区长度：798
- 翻译后氨基酸长度：265
- TranscriptVariant：This variant (2) encodes the longer isoform (2, also known as isoform L).
- 基因简介：This gene encodes a subunit of the gamma-secretase complex, which is localized to the endoplasmic reticulum and golgi apparatus. Gamma-secretase is a multi-protein enzyme that catalyzes intramembraneous proteolysis of type I transmembrane proteins and is essential for many signaling pathways, including the Notch signaling pathway. Studies suggest that the protein encoded by this locus binds directly to substrates of the gamma-secretase complex, including the beta-amyloid precursor protein which is associated with Alzheimer disease progression. This gene is required for normal embryonic development and survival, and disruption is associated with defects in the yolk sack angiogenesis, neural tube formation, and somitogenesis. A pseudogene of this gene is located on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
