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- 商品货号：G151866
- accession：NM_000527
- 基因别名：LDLR
- 基因描述：Homo sapiens low density lipoprotein receptor (LDLR), transcript variant 1, mRNA.
- 载体：现货载体
- CDS区长度：2583
- 翻译后氨基酸长度：860
- TranscriptVariant：This variant (1) represents the longest transcript and encodes the longest isoform (1).
- 基因简介：The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
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