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人ACE2(NM_021804)ORF克隆 CALU-3细胞 vero E6非洲绿猴肾细胞
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当前位置: 首页 > 质粒载体菌株 > cDNA克隆 > 人源 > 人 KMT2A (NM_005933) pcDNA3.1-3xflag-C
人 KMT2A (NM_005933) pcDNA3.1-3xflag-C
人 KMT2A (NM_005933) pcDNA3.1-3xflag-C
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    • accession：NM_005933
    • 基因别名：KMT2A
    • 基因描述：Homo sapiens lysine (K)-specific methyltransferase 2A (KMT2A), transcript variant 2, mRNA.
    • 载体：pcDNA3.1-3xflag-C
    • CDS区长度：11910
    • 翻译后氨基酸长度：3969
    • TranscriptVariant：This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    • 基因简介：This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
    • 规格：10ul 质粒
    CDS区参考序列： 点击查看序列
    翻译后氨基酸参数序列： 点击查看序列
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