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- accession：NM_001146185
- 基因别名：PEG3
- 基因描述：Homo sapiens paternally expressed 3 (PEG3), transcript variant 3, mRNA.
- 载体：现货载体
- CDS区长度：4389
- 翻译后氨基酸长度：1462
- TranscriptVariant：This variant (3) is missing a 5' non-coding exon, and uses an alternate acceptor splice site at the first coding exon compared to variant 1. This results in the use of an in-frame downstream start codon, and an isoform (2) with a shorter N-terminus compared to isoform 1.
- 基因简介：In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
