• accession：NM_017439
• 基因别名：GSAP
• 基因描述：Homo sapiens gamma-secretase activating protein (GSAP), mRNA.
• 载体：现货载体
• CDS区长度：2565
• 翻译后氨基酸长度：854
• 基因简介：Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGCTCTTCGCCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGG
CAGTGTCGGAGGCCAGCGGGGCCGGAAGCGGCGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACA
TGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGATAAGGGAAATGTCGTCTTT
GGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCA
GTTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAG
GAACGAACTTCAACCAGGATCAAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAG
GTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCTCTACCCACATATTGAAAGTCATCCTCTTC
CAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGTCGCCCAAGA
AGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTT
TGGGCTCAGTGGGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAA
AATGTATCCAGTTTTATGCTGATGAGAGCTATAACTTAATGTTTGAAGTACCCTTGGACATATCATTAAG
CAACTCAGGATTTAAACTTGTCAACTTTGGATGTGATTATCATCAATACCGAGATAAATTTTCCAAACAC
CTGACTCTGTGTGTTTTTACCAACCATACAGGAAGTTTGTGTGTATGTTACAGCCCGAAGTGTGCCTCTT
GGGGACAAATCACATATTCAGTGTTTTACATTCATAAAGGACACAGCAAGACCTTCACCACTTCTCTTGA
GAATGTTGGGTCACACATGACAAAGGGCATTACTTTTCTCAACCTTGACTATTATGTGGCTGTTTACTTA
CCTGGTCATTTCTTCCACCTACTTAATGTTCAACATCCAGACCTGATCTGCCACAATCTCTTTCTGACAG
GAAATAATGAAATGATTGATATGCTACCTCATTGCCCTTTACAGTCATTGTCAGGGTCCCTGGTATTGGA
TTGTTGTTCTGGAAAGCTCTATAGAGCACTGCTCAGCCAGTCGTCTTTATTACAGCTTCTGCAGAACACT
TGCTTAGACTGTGAGAAGATGGCTGCGTTGCACTGCGCGCTCTACTGCGGTCAAGGTGCGCAGTTCCTGG
AAGCCCAGATTATTCAGTGGATTTCTGAGAATGTCTCTGCCTGCCATTCATTTGACCTCATTCAGGAATT
TATAATTGCTTCTTCATACTGGAGTGTATATTCAGAGACAAGTAACATGGACAAACTATTGCCACATTCC
TCAGTGCTCACTTGGAATACAGAAATTCCTGGAATAACTCTTGTGACAGAAGACATTGCATTGCCTCTTA
TGAAGGTGCTCAGCTTTAAGGGCTACTGGGAAAAACTGAACTCCAACCTAGAATATGTTAAGTACGCCAA
GCCACACTTCCACTATAACAACAGTGTGGTCAGGAGAGAGTGGCACAACCTGATCTCTGAAGAGAAAACA
GGAAAAAGAAGGTCTGCGGCATACGTGAGGAATATTCTTGATAATGCAGTAAAGGTGATTTCTAACCTAG
AAGCAAGAAATTTGGGGCCAAGATTAACACCCCTCCTGCAGGAGGAAGACAGCCACCAGCGGCTGCTCAT
GGGGCTGATGGTGTCTGAGCTAAAAGACCATTTTTTGAGACACCTACAGGGTGTAGAAAAGAAGAAAATT
GAACAGATGGTTCTGGACTACATTTCAAAACTGCTGGATCTCATTTGCCACATCGTAGAAACCAATTGGA
GGAAACATAATCTTCATTCCTGGGTTCTCCACTTCAATAGTCGTGGCAGTGCTGCTGAATTTGCAGTTTT
TCACATCATGACCAGGATTCTGGAAGCTACAAACAGTTTGTTTTTACCTCTGCCTCCTGGTTTTCATACT
CTGCACACCATCCTCGGGGTCCAGTGTCTCCCTTTGCATAACCTGCTGCATTGCATTGACAGTGGAGTGT
TGCTTCTCACTGAAACAGCTGTCATAAGGCTCATGAAAGATCTGGATAATACAGAGAAAAATGAAAAACT
GAAATTCAGTATCATTGTGCGGCTTCCTCCGCTTATTGGGCAGAAGATTTGTAGACTTTGGGATCATCCT
ATGAGTTCTAACATCATTTCGCGGAACCACGTGACGCGACTGCTTCAGAACTATAAGAAACAGCCTCGGA
ATTCTATGATTAACAAGTCATCGTTCAGTGTAGAATTTCTGCCTCTGAACTACTTCATTGAAATTCTGAC
AGATATAGAGTCCTCCAATCAAGCCCTGTATCCTTTTGAAGGACATGACAATGTGGATGCAGAATTTGTA
GAGGAAGCAGCTCTGAAACACACCGCGATGCTTTTAGGCTTATGA

翻译后氨基酸参数序列： 点击查看序列

ATGGCTCTTCGCCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGG
CAGTGTCGGAGGCCAGCGGGGCCGGAAGCGGCGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACA
TGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGATAAGGGAAATGTCGTCTTT
GGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCA
GTTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAG
GAACGAACTTCAACCAGGATCAAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAG
GTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCTCTACCCACATATTGAAAGTCATCCTCTTC
CAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGTCGCCCAAGA
AGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTT
TGGGCTCAGTGGGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAA
AATGTATCCAGTTTTATGCTGATGAGAGCTATAACTTAATGTTTGAAGTACCCTTGGACATATCATTAAG
CAACTCAGGATTTAAACTTGTCAACTTTGGATGTGATTATCATCAATACCGAGATAAATTTTCCAAACAC
CTGACTCTGTGTGTTTTTACCAACCATACAGGAAGTTTGTGTGTATGTTACAGCCCGAAGTGTGCCTCTT
GGGGACAAATCACATATTCAGTGTTTTACATTCATAAAGGACACAGCAAGACCTTCACCACTTCTCTTGA
GAATGTTGGGTCACACATGACAAAGGGCATTACTTTTCTCAACCTTGACTATTATGTGGCTGTTTACTTA
CCTGGTCATTTCTTCCACCTACTTAATGTTCAACATCCAGACCTGATCTGCCACAATCTCTTTCTGACAG
GAAATAATGAAATGATTGATATGCTACCTCATTGCCCTTTACAGTCATTGTCAGGGTCCCTGGTATTGGA
TTGTTGTTCTGGAAAGCTCTATAGAGCACTGCTCAGCCAGTCGTCTTTATTACAGCTTCTGCAGAACACT
TGCTTAGACTGTGAGAAGATGGCTGCGTTGCACTGCGCGCTCTACTGCGGTCAAGGTGCGCAGTTCCTGG
AAGCCCAGATTATTCAGTGGATTTCTGAGAATGTCTCTGCCTGCCATTCATTTGACCTCATTCAGGAATT
TATAATTGCTTCTTCATACTGGAGTGTATATTCAGAGACAAGTAACATGGACAAACTATTGCCACATTCC
TCAGTGCTCACTTGGAATACAGAAATTCCTGGAATAACTCTTGTGACAGAAGACATTGCATTGCCTCTTA
TGAAGGTGCTCAGCTTTAAGGGCTACTGGGAAAAACTGAACTCCAACCTAGAATATGTTAAGTACGCCAA
GCCACACTTCCACTATAACAACAGTGTGGTCAGGAGAGAGTGGCACAACCTGATCTCTGAAGAGAAAACA
GGAAAAAGAAGGTCTGCGGCATACGTGAGGAATATTCTTGATAATGCAGTAAAGGTGATTTCTAACCTAG
AAGCAAGAAATTTGGGGCCAAGATTAACACCCCTCCTGCAGGAGGAAGACAGCCACCAGCGGCTGCTCAT
GGGGCTGATGGTGTCTGAGCTAAAAGACCATTTTTTGAGACACCTACAGGGTGTAGAAAAGAAGAAAATT
GAACAGATGGTTCTGGACTACATTTCAAAACTGCTGGATCTCATTTGCCACATCGTAGAAACCAATTGGA
GGAAACATAATCTTCATTCCTGGGTTCTCCACTTCAATAGTCGTGGCAGTGCTGCTGAATTTGCAGTTTT
TCACATCATGACCAGGATTCTGGAAGCTACAAACAGTTTGTTTTTACCTCTGCCTCCTGGTTTTCATACT
CTGCACACCATCCTCGGGGTCCAGTGTCTCCCTTTGCATAACCTGCTGCATTGCATTGACAGTGGAGTGT
TGCTTCTCACTGAAACAGCTGTCATAAGGCTCATGAAAGATCTGGATAATACAGAGAAAAATGAAAAACT
GAAATTCAGTATCATTGTGCGGCTTCCTCCGCTTATTGGGCAGAAGATTTGTAGACTTTGGGATCATCCT
ATGAGTTCTAACATCATTTCGCGGAACCACGTGACGCGACTGCTTCAGAACTATAAGAAACAGCCTCGGA
ATTCTATGATTAACAAGTCATCGTTCAGTGTAGAATTTCTGCCTCTGAACTACTTCATTGAAATTCTGAC
AGATATAGAGTCCTCCAATCAAGCCCTGTATCCTTTTGAAGGACATGACAATGTGGATGCAGAATTTGTA
GAGGAAGCAGCTCTGAAACACACCGCGATGCTTTTAGGCTTATGA