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- accession：NM_001037741
- 基因别名：Gpx4;PHGPx; snGPx; mtPHGPx; 1700027O09Rik
- 基因描述：Mus musculus glutathione peroxidase 4 (Gpx4)， transcript variant 1， mRNA.
- 载体：pAAV-CAG-GFP、pAAV-mcs
- CDS区长度：762
- 翻译后氨基酸长度：253
- TranscriptVariant：This variant (1) contains a different exon for the 5’ UTR and 5’ coding region， compared to variant 2. The encoded isoform (1) is longer and has a distinct N-terminus， compared to isoform 2. A similar transcript in rat contains a nuclear transit peptide sequence; existence of a similar sequence in mouse needs to be experimentally verified.
- 基因简介：Glutathione peroxidase catalyzes the reduction of hydrogen peroxide， organic hydroperoxide， and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation， rat produces proteins that localize to the nucleus， mitochondrion， and cytoplasm. In mice， experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Two pseudogenes exist for this gene， one on chromosome 10 and one on chromosome 17. [provided by RefSeq， Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
