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- accession：NM_001112802
- 基因别名：SLC8A1
- 基因描述：Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant D, mRNA.
- 载体：现货载体
- CDS区长度：2814
- 翻译后氨基酸长度：937
- TranscriptVariant：This variant (D) has multiple differences in the coding region but maintains the reading frame, compared to variant A. This variant encodes isoform D, also known as NaCa3, NCX1.3, or the kidney isoform, which is 36 aa shorter than isoform A.
- 基因简介：In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
