• accession：NM_021145
• 基因别名：DMTF1
• 基因描述：Homo sapiens cyclin D binding myb-like transcription factor 1 (DMTF1), transcript variant 1, mRNA.
• 载体： 现货载体
• CDS区长度：2283
• 翻译后氨基酸长度：760
• TranscriptVariant：This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.
• 基因简介：This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
• 载体信息：自有图片地址
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGAGCACAGTGGAAGAGGATTCTGACACAGTAACAGTAGAAACTGTGAACTCTGTGACTTTGACTCAGGACACAGAAGGGAATCTCATTCTTCACTGCCCTCAGAATGAAGCGGATGAAATAGACTCAGAAGATAGTATTGAACCTCCACATAAAAGGCTTTGTTTGTCCTCTGAGGATGATCAGAGTATTGATGATTCTACTCCTTGCATATCAGTTGTTGCACTTCCACTTTCAGAAAATGATCAGAGCTTTGAAGTGACCATGACTGCAACCACAGAAGTAGCAGATGATGAGGTTACTGAGGGGACTGTGACACAGATACAGATTTTGCAGAATGAGCAACTAGATGAAATATCTCCCTTGGGTAACGAGGAAGTTTCAGCAGTTAGCCAAGCATGGTTTACAACTAAAGAAGATAAGGATTCTCTGACTAATAAAGGACATAAATGGAAGCAGGGGATGTGGTCCAAGGAAGAAATTGATATTTTGATGAACAATATTGAACGCTATCTTAAGGCACGCGGAATAAAAGATGCTACAGAAATCATCTTTGAGATGTCAAAAGACGAAAGAAAAGATTTCTACAGGACTATAGCATGGGGTCTGAACCGGCCTTTGTTTGCAGTTTATAGAAGAGTGCTTCGCATGTATGATGACAGAAACCATGTGGGAAAATATACACCTGAAGAAATTGAGAAGCTCAAGGAGCTCCGGATAAAGCATGGCAATGACTGGGCAACAATAGGGGCGGCGCTAGGAAGAAGTGCATCTTCTGTCAAAGATCGGTGCCGACTGATGAAGGATACTTGCAACACAGGGAAGTGGACAGAAGAAGAAGAAAAGAGACTTGCAGAAGTGGTTCATGAGTTGACAAGCACTGAGCCAGGTGACATAGTCACACAGGGTGTGTCTTGGGCAGCTGTGGCTGAACGAGTCGGTACCCGCTCAGAAAAGCAATGTCGTTCTAAATGGCTCAACTACCTGAATTGGAAACAGAGTGGGGGTACTGAATGGACCAAGGAAGATGAAATCAATCTCATCCTCAGGATAGCAGAACTTGATGTAGCTGATGAAAATGACATTAACTGGGATCTGTTAGCTGAGGGATGGAGTAGTGTCCGTTCACCACAATGGCTACGAAGTAAATGGTGGACCATCAAAAGGCAAATTGCAAACCATAAGGATGTTTCGTTCCCTGTCTTAATAAAAGGTCTTAAACAGTTACATGAGAACCAAAAAAACAACCCAACGCTTTTGGAGAATAAATCAGGATCTGGAGTTCCAAACAGTAATACCAATTCCAGTGTGCAGCATGTTCAGATAAGAGTTGCCCGCTTGGAAGATAATACAGCCATCTCTTCTAGCCCCATGGCAGCATTGCAGATTCCAGTCCAGATCACCCATGTTTCTTCAGCAGACTCTCCTGCTACCGTTGACTCAGAAACAATAACACTAAACAGTGGAACACTACAGACATTTGAGATTCTTCCCTCTTTCCATCTACAGCCCACTGGCACTCCAGGCACCTACCTACTTCAAACAAGCTCAAGCCAAGGCCTTCCCCTAACTCTGACTGCTAGTCCCACAGTAACCCTGACAGCTGCTGCTCCTGCTTCTCCTGAACAGATTATTGTTCATGCTTTATCCCCAGAACATTTGTTGAACACAAGTGATAATGTTACAGTGCAGTGTCACACACCAAGAGTCATCATTCAGACTGTTGCCACAGAGGACATCACTTCTTCCATATCCCAAGCAGAACTGACAGTCGATAGTGATATTCAGTCATCTGATTTTCCTGAGCCTCCAGACGCCCTAGAAGCAGACACTTTCCCAGATGAAATTCATCACCCTAAGATGACTGTGGAGCCATCATTTAATGATGCTCATGTATCCAAATTCAGTGACCAAAATAGCACAGAACTGATGAATAGTGTTATGGTCAGAACAGAAGAAGAAATCTCTGACACCGACCTTAAACAAGAGGAATCACCCTCTGATTTAGCCAGTGCTTATGTTACTGAGGGTTTAGAGTCTCCCACTATAGAAGAACAAGTTGATCAAACAATTGATGATGAAACAATACTTATCGTTCCTTCACCACATGGCTTTATCCAGGCATCTGATGTTATAGATACTGAATCTGTCTTGCCTTTGACAACACTAACAGATCCCATACTCCAACATCATCAGGAAGAATCAAATATCATTGGATCATCCTTGGGCAGTCCTGTTTCAGAAGATTCAAAGGATGTCGAAGATTTGGTAAACTGTCATTAG

翻译后氨基酸参数序列： 点击查看序列

ATGAGCACAGTGGAAGAGGATTCTGACACAGTAACAGTAGAAACTGTGAACTCTGTGACTTTGACTCAGGACACAGAAGGGAATCTCATTCTTCACTGCCCTCAGAATGAAGCGGATGAAATAGACTCAGAAGATAGTATTGAACCTCCACATAAAAGGCTTTGTTTGTCCTCTGAGGATGATCAGAGTATTGATGATTCTACTCCTTGCATATCAGTTGTTGCACTTCCACTTTCAGAAAATGATCAGAGCTTTGAAGTGACCATGACTGCAACCACAGAAGTAGCAGATGATGAGGTTACTGAGGGGACTGTGACACAGATACAGATTTTGCAGAATGAGCAACTAGATGAAATATCTCCCTTGGGTAACGAGGAAGTTTCAGCAGTTAGCCAAGCATGGTTTACAACTAAAGAAGATAAGGATTCTCTGACTAATAAAGGACATAAATGGAAGCAGGGGATGTGGTCCAAGGAAGAAATTGATATTTTGATGAACAATATTGAACGCTATCTTAAGGCACGCGGAATAAAAGATGCTACAGAAATCATCTTTGAGATGTCAAAAGACGAAAGAAAAGATTTCTACAGGACTATAGCATGGGGTCTGAACCGGCCTTTGTTTGCAGTTTATAGAAGAGTGCTTCGCATGTATGATGACAGAAACCATGTGGGAAAATATACACCTGAAGAAATTGAGAAGCTCAAGGAGCTCCGGATAAAGCATGGCAATGACTGGGCAACAATAGGGGCGGCGCTAGGAAGAAGTGCATCTTCTGTCAAAGATCGGTGCCGACTGATGAAGGATACTTGCAACACAGGGAAGTGGACAGAAGAAGAAGAAAAGAGACTTGCAGAAGTGGTTCATGAGTTGACAAGCACTGAGCCAGGTGACATAGTCACACAGGGTGTGTCTTGGGCAGCTGTGGCTGAACGAGTCGGTACCCGCTCAGAAAAGCAATGTCGTTCTAAATGGCTCAACTACCTGAATTGGAAACAGAGTGGGGGTACTGAATGGACCAAGGAAGATGAAATCAATCTCATCCTCAGGATAGCAGAACTTGATGTAGCTGATGAAAATGACATTAACTGGGATCTGTTAGCTGAGGGATGGAGTAGTGTCCGTTCACCACAATGGCTACGAAGTAAATGGTGGACCATCAAAAGGCAAATTGCAAACCATAAGGATGTTTCGTTCCCTGTCTTAATAAAAGGTCTTAAACAGTTACATGAGAACCAAAAAAACAACCCAACGCTTTTGGAGAATAAATCAGGATCTGGAGTTCCAAACAGTAATACCAATTCCAGTGTGCAGCATGTTCAGATAAGAGTTGCCCGCTTGGAAGATAATACAGCCATCTCTTCTAGCCCCATGGCAGCATTGCAGATTCCAGTCCAGATCACCCATGTTTCTTCAGCAGACTCTCCTGCTACCGTTGACTCAGAAACAATAACACTAAACAGTGGAACACTACAGACATTTGAGATTCTTCCCTCTTTCCATCTACAGCCCACTGGCACTCCAGGCACCTACCTACTTCAAACAAGCTCAAGCCAAGGCCTTCCCCTAACTCTGACTGCTAGTCCCACAGTAACCCTGACAGCTGCTGCTCCTGCTTCTCCTGAACAGATTATTGTTCATGCTTTATCCCCAGAACATTTGTTGAACACAAGTGATAATGTTACAGTGCAGTGTCACACACCAAGAGTCATCATTCAGACTGTTGCCACAGAGGACATCACTTCTTCCATATCCCAAGCAGAACTGACAGTCGATAGTGATATTCAGTCATCTGATTTTCCTGAGCCTCCAGACGCCCTAGAAGCAGACACTTTCCCAGATGAAATTCATCACCCTAAGATGACTGTGGAGCCATCATTTAATGATGCTCATGTATCCAAATTCAGTGACCAAAATAGCACAGAACTGATGAATAGTGTTATGGTCAGAACAGAAGAAGAAATCTCTGACACCGACCTTAAACAAGAGGAATCACCCTCTGATTTAGCCAGTGCTTATGTTACTGAGGGTTTAGAGTCTCCCACTATAGAAGAACAAGTTGATCAAACAATTGATGATGAAACAATACTTATCGTTCCTTCACCACATGGCTTTATCCAGGCATCTGATGTTATAGATACTGAATCTGTCTTGCCTTTGACAACACTAACAGATCCCATACTCCAACATCATCAGGAAGAATCAAATATCATTGGATCATCCTTGGGCAGTCCTGTTTCAGAAGATTCAAAGGATGTCGAAGATTTGGTAAACTGTCATTAG