• 名称：ABT-263 (Navitoclax)
• 简介：ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w).ABT-263 maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
• CASNO：923564-51-6
• 分子式：C47H55ClF3N5O6S3
• 分子量：974.6
• SMILES：CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
• 保持条件：at -20°C 3 years Powder
• 同名：ABT263
• 纯度：>98%
• 应用：Bcl-2 inhibitor
• 作用机制：Inhibitor