• 名称：Aprepitant (MK-0869)
• 简介：Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.
• CASNO：170729-80-3
• 分子式：C23H21F7N4O3
• 分子量：534.4
• SMILES：C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
• 保持条件：at -20°C 3 years Powder
• 同名：MK0869, MK-869, L-754030, Emend
• 纯度：>98%
• 应用：neurokinin-1 receptor antagonist
• 作用机制：Antagonist