• 名称：Semagacestat (LY450139)
• 简介：Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
• CASNO：425386-60-3
• 分子式：C19H27N3O4
• 分子量：361.4
• SMILES：C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
• 保持条件：at -20°C 3 years Powder
• 同名：LY-450139
• 纯度：>98%
• 应用：Gamma-secretase inhibitor
• 作用机制：Inhibitor