• 名称：SCH 900776 (MK-8776)
• 简介：SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.
• CASNO：891494-63-6
• 分子式：C15H18BrN7
• 分子量：376.25
• SMILES：NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
• 保持条件：at -20°C 3 years Powder
• 同名：SCH-900776, MK-8776, MK8776, MK 8776
• 纯度：>98%
• 应用：Chk1 inhibitor
• 作用机制：Inhibitor