• 名称：ALK-IN-1 (Brigatinib analog, AP26113 analog)
• 简介：AP26113 is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line. In a panel of EML4-ALK or NPM-ALK-positive cell lines, AP26113 has IC50 values of 4-31 nM. AP26113 is effective against sensitive and resistant H3122 cells, reducing cell growth, suppressing ALK phosphorylation, and inducing apoptosis. In Ba/F3 cells expressing native or mutant EML4-ALK, AP26113 was active at IC50s of 10 and 24 nM, respectively.
• CASNO：1197958-12-5
• 分子式：C26H34ClN6O2P
• 分子量：529.01
• SMILES：CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC
• 保持条件：at -20°C 3 years Powder
• 同名：AP-26113
• 纯度：>98%
• 应用：ALK inhibitor
• 作用机制：Inhibitor