• 名称：Quarfloxin (CX-3543)
• 简介：Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
• CASNO：865311-47-3
• 分子式：C35H33FN6O3
• 分子量：604.67
• SMILES：CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
• 保持条件：at -20°C 3 years Powder
• 同名：CX 3543; Quarfloxacin; CX3543; CX-3543
• 纯度：>98%
• 应用：rRNA biogenesis inhibitor
• 作用机制：Inhibitor